Intravenous immunoglobulin in BK virus nephropathy
نویسندگان
چکیده
The incidence of post transplant viral infections has increased with the use of more potent immunosuppressive regimens. Consequently, BK virus nephropathy (BKVN) has arisen as a significant cause of graft dysfunction and loss. Reduction of immunosuppression is the first line management of post-transplant viral infections. Other therapies such as intravenous immunoglobulin (IVIg), cidofovir, leflunomide and fluoroquinolones have been tried with varying degrees of
منابع مشابه
Active management versus minimization of immunosuppressives of BK virus-associated nephropathy after a kidney transplant.
OBJECTIVES Thus far, there is no active treatment for BK virus-associated nephropathy after a kidney transplant that has proven to be effective. We sought to assess the effectiveness of treatment with leflunomide, intravenous immunoglobulin, and ciprofloxacin on graft outcome after 1 year compared with a historical group treated with reduced immunosuppressive medications strategy. MATERIALS A...
متن کاملLong-Term Follow-Up of Active Treatment Versus Minimization of Immunosuppressive Agents in Patients With BK Virus-Associated Nephropathy After Kidney Transplant.
OBJECTIVES There is no active treatment for postrenal transplant BK virus-associated nephropathy proven to be effective so far. We assessed the effectiveness of actively treating this condition with combined leflunomide, intravenous immunoglobulin, and ciprofloxacin on long-term graft outcome compared with minimization of immunosuppressive drugs. MATERIALS AND METHODS Kidney transplant recipi...
متن کاملبررسی فراوانی نفروپاتی ناشی از ویروس BK در نمونه های بیوپسی
A Ghafari Moghaddam [1] , MD M Taghizadieh [2] , MD N Aghakhani [3] , MD N Ebrahimi [4] , MD E Rahimi [5] , MDM Ghasemi-rad [6] , MD, S Zafarshams pour [7] , MD Received: 29 April, 2007 Accepted: 29 Oct, 2008 Abstract Background &Aims: BK virus nephropathy is recognized as a cause of graft loss in renal transplant patients. The disorder may be related to the introduction of new, potent im...
متن کاملFirst documented case of BK nephropathy in kidney transplant recipient in Croatia: usage of urine cytology in evaluation process.
BK virus associated nephropathy (BKVAN) in transplanted kidney, although recognized as a distinct entity in the 1970-es, continues to represent a challenge in kidney transplantation, mainly because the optimal treatment approach has not been determined yet. The fact that about 10-20% of patients have simultaneously some stage of acute rejection, complicate the treatment even more. Herein we pre...
متن کاملبررسی مولکولی فعالیت مجدد ویروس BK در ادرار بیماران پیوند کلیه
Background & Amis: BK polyomavirus (BKV) is common infection of childhood that persists in kidney epithelium. BKV reactivation characterized by viruria occurs in 35% to 57% of renal allograft recipients. BK virus was detected in serum samples in 6% to 29% of these patients. BKV-associated nephropathy occurs in as many as 8% of renal allograft recipients and may lead to . This study was carri...
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